The 2011 Cal Poly Mustangs football team represented California Polytechnic State University, San Luis Obispo as member of the Great West Conference (GWC) during the 2011 NCAA Division I FCS football season. Led by third-year head coach Tim Walsh, Cal Poly compiled an overall record of 6–5 with a mark of 3–1 in conference play, sharing the GWC with North Dakota. The Mustangs played home games at Alex G. Spanos Stadium in San Luis Obispo, California.
With a win over South Dakota on October 29, Cal Poly clinched a share of the conference championship, the program's fourth conference title since the GWC's creation in 2004. The Mustangs became a football-only member of the Big Sky Conference in 2012.
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